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events Sep 4, 2015

The Role of The Non Protein-coding Transcripts in Cancer by Prof. Leandro Castellano

Internal Talk at Stratified Medical — now known as BenevolentAI

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Sep 4, 2015


12:00 AM




BenevolentAI, 40 Churchway, NW1 1LW

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Professor Leandro Castellano, Reasearch Associate at the faculty of Medicine, Department of Surgery and Cancer at Imperial College London gave an internal talk about his work on the Role of the Non Protein-coding Transcripts in Cancer.

Within tumours, individual cells often differ genetically while also transitioning between specific cell states linked to disease progression and treatment failure. Dr Castellano's group is investigating how non-coding RNAs (ncRNAs) interacting with proteins and DNA control these phenotypes. 

ncRNAs can be short (< 200bp) including the class of microRNAs or longer (> 200bp) and called long non-coding RNAs: both are often dysregulated in cancers, either enhancing or slowing oncogenesis by various mechanisms.  By focusing on the roles of these non-coding RNAs in orchestrating transitions, such as the epithelial-mesenchymal transition that facilitates metastasis, and the differentiation of stem-like tumour cells into differentiated progeny, they hope to elucidate functions of this previously unrecognised layer of regulatory RNAs.

Non-coding RNAs implicated in maintaining these tumour cell states can then offer diagnostic, prognostic and therapeutic potential once their contribution to tumour behaviour is established.