Project Rep and PK/PD modeller

BenevolentAI, founded in 2013, creates and applies AI technologies to transform the way medicines are discovered and developed. BenevolentAI seeks to improve patient’s lives by applying technology designed to generate better data decision making and in doing so lower drug development costs, decrease failure rates and increase the speed at which medicines are generated. The company has developed the Benevolent Platform™ - a discovery platform used by BenevolentAI scientists to find new ways to treat disease and personalise drugs to patients.

BenevolentAI is HQ’d in London with a research facility in Cambridge (UK) and further offices in New York and Antwerp. BenevolentAI has active R&D drug programmes from discovery to PhaseIIb in disease areas such as ALS, Parkinson’s, Ulcerative Colitis and Sarcopenia.

The role

We are looking for a DMPK professional, preferably at principal scientist level, with a good level of practical experience of interpreting ADME and PK results as well as providing non clinical PK/PD support in a multi-functional drug discovery project team environment.

Based at the Babraham Research Campus in Cambridge (UK), working with artificial intelligence, deep learning, informatics, biological sciences, drug discovery and clinical translation/commercialisation colleagues to devise creative ways to reimagine the way medicines are discovered.

Primary Responsibilities

The candidate will be working as part of the DMPK team supporting small molecule lead optimisation and development, as well as AI and machine learning driven target identification and validation teams. The team are looking for a motivated individual primarily to support our projects as a DMPK representative, working closely with your DMPK, Chemistry and Biology colleagues to develop practical screening cascades. Further to that the individual will have an important role in helping to shape the non clinical PK/PD strategy for projects. They will be expected to engage fully in multi-functional collaborations to support profiling of drug candidates, building a clear picture of IVIVC PK/PD, ultimately to ensure translation from in vitro data and in vivo non-clinical studies to prediction of efficacy and safety in patients. The individual will also support PK/PD models for hypothesis testing and to inform decision-making for Target ID, ideally training other staff.

The individual should be a confident communicator, able to advise teams on selection and interpretation of studies and to design focussed experiments.

We’re looking for someone with...

  • A degree and preferably a PhD in a relevant discipline (pharmacology, bioengineering,
    pharmacokinetics/pharmacodynamics, etc.)

  • A good understanding of pharmacology and pharmacologic processes related to
    disease and drug mechanisms.

  • A good understanding of ADME principles and experience of PK scaling, and possibly PBPK.They will have experience providing scientific and technical input within a multifunctional project team environment.

  • Demonstrated experience in developing and executing effective nonclinical
    PK/PD strategies from early discovery through to development.

  • Experience with PK/PD software such as Phoenix win-nonlin, Gastroplus, Berkeley Madonna etc. would be and advantage.

  • Innovative, self-motivated, team-oriented scientist with good written and verbal
    communication skills, able to handle multiple-projects.

  • A proactive and positive problem-solving mindset, confident to contribute strategically and implement ideas to drive assays, processes and targets forward. You should be comfortable working in a fast paced, dynamic environment and on multiple projects with changing priorities and deadlines, working closely with colleagues to schedule studies in-house and balancing with outsourcing external studies where required.

  • Excellent communication skills, able to collaborate with internal and external colleagues at all levels. You will be willing to share knowledge, connecting across functions and with more junior members of the team.

  • A drive to keep up to date with advances in technology, literature, updates in industry best practice and regulatory guidance and to champion new initiatives.There is also an opportunity to take on line management responsibilities, and to assist in the development of staff within the DMPK team.

Who are we?

We have assembled a diverse, exceptionally talented and spirited team to tackle the most pressing and challenging problems at the intersection of artificial intelligence and drug discovery. We bring our ideas and passion for new technology and medicine discover to life by questioning traditional scientific dogmas.

Our core values reflect who we are and how we work and they are so important to achieve our mission: Bring better medicine to patients faster.

Put patients first | Drive to delivery | Break boundaries | Own the solution.

Watch our team talking about the work we do at BenevolentAI

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